Publications

Google Scholar
PubMed Bibliography

Refereed Publications

2024

47. Integration of FEBio as an Instructional Tool in the Undergraduate Biomechanics Curriculum

David Jiang, David W. Grainger, Jeffrey A. Weiss, Lucas H. Timmins

ASME Journal of Biomechanical Engineering

DOI: 10.1007/s10237-023-01814-2

46. Influence of Material Parameter Variability on the Predicted Coronary Artery Biomechanics Environment via Uncertainty Quantification

Caleb C. Berggren, David Jiang, Y.F. Jack Wang, Jake A. Bergquist, Lindsay C. Rupp, Zexin Liu, Rob S. MacLeod, Akil Narayan, Lucas H. Timmins

Biomechanics and Modeling in Mechanobiology

DOI: 10.1007/s10237-023-01814-2

2023

45. Sleeve Gastrectomy May Improve Arterial Health in Obese Adolescents

Carson Hoffmann, Andrew Morris, Lucas Timmins, Xaingqin Cui, Riti Sachdeva, Stephanie Walsh, Mark Wulkan, Luke Brewster

Nutrition, Metabolism, and Cardiovascular Disease

DOI: 10.1016/j.numecd.2023.07.001

44. Flow-Based Method Demonstrates Improved Accuracy for Calculating Wall Shear Stress in Arterial Flows from 4D Flow MRI Data

Elliott R. Hurd, Elizabeth Iffrig, David Jiang, John N. Oshinski, Lucas H. Timmins

Journal of Biomechanics

DOI: 10.1016/j.jbiomech.2022.111413

43. Collagen Molecular Damage is a Hallmark of Early Atherosclerosis Development

Kelly A. Smith, Allen L. Lin, Alexander H. Stevens, S. Michael Yu. Jeffrey A. Weiss, Lucas H. Timmins

Journal of Cardiovascular Translational Research

DOI: 10.1007/s12265-022-10316-y

42. Comparison of Prospective and Retrospective Gated 4D Flow Cardiac MR Image Acquisitions in the Carotid Bifurcation

Elliott R. Hurd, Mengjiao Han, Jason K. Mendes, J. Rock Hadley, Chris R. Johnson, Edward V.R. DiBella, John N. Oshinski, Lucas H. Timmins 

Cardiovascular Engineering & Technology

DOI: 10.1007/s13239-022-00630-6

2022

41. A New Method for Quantifying Abdominal Aorta Wall Shear Stress Using Phase Contrast Magnetic Resonance and the Womersley Solution

Elizabeth Iffrig, Lucas H. Timmins, Retta El Sayed, W. Robert Taylor, John N. Oshinski

ASME Journal of Biomechanics Engineering

DOI: 10.1115/1.4054236

40. Model-Directed Design of Tissue Engineering Scaffolds

Elizabeth Cosgriff-Hernandez, Lucas H. Timmins

ACS Biomaterials Science & Engineering

DOI: 10.1021/acsbiomaterials.1c01386

2021

39. A Non-Biased Approached to Measure Three-Dimensional Fiber Orientation Distribution Function (ODF) in Fibrous Materials

Adam Rauff, Lucas H. Timmins, Ross T. Whitaker, Jeffrey A. Weiss

IEEE Transactions on Medical Imaging

DOI: 10.1109/TMI.2021.3115716

38. Considerations for Analysis of Endothelial Shear Stress and Strain in FSI Models of Atherosclerosis

Miten Patel, Fotios Savvopoulos, Caleb C. Berggren, Lydia Aslanidou, Lucas H. Timmins, Ranil de Silva, Ryan M. Pedrigi, Rob Krams    

Journal of Biomechanics

DOI: 10.1016/j.jbiomech.2021.110720

37. Effects of Subject-Specific, Spatially-Reduces, and Idealized Boundary Conditions on the Predicted Hemodynamic Environment in the Murine Aorta

Kelly A. Smith, Samer S. Merchant, Edward W. Hsu, Lucas H. Timmins

Annals of Biomedical Engineering

DOI: 10.1007/s10439-021-02851-7

36. On the Use of Constrained Reactive Mixtures of Solids to Model Finite Deformation Isothermal Elastoplasticity and Elastoplastic Damage Mechanics

Brandon K. Zimmerman, David Jiang, Jeffrey A. Weiss, Lucas H. Timmins, Gerard A. Ateshian

Journal of the Mechanics and Physics of Solids

DOI: 10.1016/j.jmps.2021.104534

35. Effect of Patient-Specific Coronary Flow Reserve (CFR) Values on the Accuracy of Virtual Fractional Flow Reserve (vFFR)

Jackson Hair, Lucas Timmins, Retta El Sayed, Habib Samady, John Oshinski

Frontier in Bioengineering and Biotechnology

DOI: 10.3389/fcvm.2021.663767 

2020

34. Catheter-Based Optical Approaches for Cardiovascular Medicine: Progress, Challenges and New Directions

Chao Huang, Nathan Knighton, Lucas H. Timmins, Frank B. Sachse

Progress in Biomedical Engineering

DOI: 10.1088/2516-1091/ab8af8

33. Expert Consensus on the Assessment of Wall Shear Stress in Human Coronary Arteries: Existing Methodologies, Technical Considerations, and Clinical Applications

Frank Gijsen, Yuki Katagiri, Peter Barlis, Christos Bourantas, Carlos Collet, Umit Coskun, Joost Daemen, Jouke Dijkstra, Elazer Edelman, Paul Evans, Kim Van Der Heiden, Rod Hose, Bon-Kwon Koo, Rob Krams, Alison Marsden, Francesco Migliavacca, Yoshinobu Onuma, Andrew Ooi, Eric Poon, Habib Samady, Peter Stone, Kuniaki Takahashi, Dalin Tang, Vikas Thondapu, Erhan Tenekecioglu, Lucas Timmins, Ryo Torii, Jolanda Wentzel, Patrick Serruys

European Heart Journal

DOI:10.1093/eurheartj/ehz551

2019

32. The Influence of Multidirectional Shear Stress on Plaque Progression and Destabilization in Human Coronary Arteries

Annette M. Kok, David S. Molony, Lucas H. Timmins, Yi-An Ko, Eric Boersma, Parham Eshtehardi, Jolanda J. Wentzel, Habib Samady

EuroIntervention

DOI: 10.4244/EIJ-D-18-00529

31. Impact of Combined Plaque Structural Stress and Wall Shear Stress on Coronary Plaque Progression, Regression, and Changes in Composition

Charis Costopoulos, Lucas H. Timmins, Yuan Huang, Olivia Y. Hung, David S. Molony, Adam J. Brown, Emily L. Davis, Zhongzhao Teng, Jonathan H. Gillard, Habib Samady, Martin R. Bennett 

European Heart Journal

DOI: 10.1093/eurheartj/ehz132

2018

30. Establishment of an Automated Algorithm Utilizing Optical Coherence Tomography and Micro-Computed Tomography Imaging to Reconstruct the 3D Deformed Stent Geometry

Mark R. Elliott, Dan Kim, David S. Molony, Liam Morris, Habib Samady, Sarang Joshi, Lucas H. Timmins

IEEE Transactions on Medical Imaging

DOI: 10.1109/TMI.2018.2870714

2017

29. Disturbed Flow Promotes Arterial Stiffening through Thrombospondin-1 (TSP-1)

Chan Woo Kim, Anastassia Pokutta-Paskaleva, Sandeep Kumar, Lucas H. Timmins, Andrew D. Morris, Dong-Won Kang, Sidd Dalal, Tatiana Chadid, Katie M. Kuo, Julia Raykin, Haiyan Li, Hiromi Yanagisawa, Rudolph L. Gleason Jr, Hanjoong Jo, Luke P. Brewster

Circulation

DOI: 10.1161/CIRCULATIONAHA.116.026361

28. Pulsatile Flow Leads to Intimal Flap Motion and Flow Reversal in an In Vitro Model of Type B Aortic Dissection

Joav Birjiniuk, Lucas H. Timmins, Mark Young, Bradley G. Leshnower, John N. Oshinski, David N. Ku, Ravi K. Veeraswamy

Cardiovascular Engineering and Technology

DOI: 10.1007/s13239-017-0312-3

27. An Endovascular Model of Ischemic Myopathy from Peripheral Artery Disease

Chandler A. Long, Lucas H. Timmins, Panagiotis Koutakis, Traci T. Goodchild, David J. Lefer, Iraklis I. Pipinos, George P. Casale, Luke P. Brewster

Journal of Vascular Surgery

DOI: 10.1016/j.jvs.2016.07.127

26. Oscillatory Coronary Wall Shear Stress is A Dominant Flow Characteristic in Lesion Progression Patterns and Plaque Vulnerability in Patients with Coronary Artery Disease

Lucas H. Timmins, David S. Molony, Parham Eshtehardi, Michael C. McDaniel, John N. Oshinski, Don P. Giddens, Habib Samady

Journal of The Royal Society Interface

DOI: 10.1098/rsif.2016.0972

25. Quantification of the Focal Progression of Coronary Atherosclerosis Through Automated Co-registration of Virtual Histology-Intravascular Ultrasound Imaging Data

Lucas H. Timmins, David S. Molony, Parham Eshtehardi, Emad Rasoul-Arzrumly, Adrian Lam, Olivia Y. Hung, Michael C. McDaniel, John N. Oshinski, Don P. Giddens, Habib Samady

International Journal of Cardiovascular Imaging

DOI: 10.1007/s10554-016-0969-y

2016

24. Evaluation of a Framework for the Co-registration of Intravascular Ultrasound and Optical Coherence Tomography Coronary Artery Pullbacks

David S. Molony, Lucas H. Timmins, Emad Rasoul-Arzrumly, Habib Samady, Don P. Giddens

Journal of Biomechanics

DOI: 10.1016/j.jbiomech.2016.10.040

23. Comparison of Angiographic and IVUS Derived Coronary Geometric Reconstructions for Evaluation of Hemodynamics and Association with Coronary Artery Disease Progression

Lucas H. Timmins, Jin Suo, Parham Eshtehardi, David S. Molony, Michael C. McDaniel, John N. Oshinski, Don P. Giddens, Habib Samady

International Journal of Cardiovascular Imaging

DOI: 10.1007/s10554-016-0918-9

22. Fibrin Network Changes in Neonates After Cardiopulmonary Bypass

Ashley C. Brown, Riley H. Hannan, Lucas H. Timmins, Janet D. Fernandez, Thomas H. Barker, Nina A. Guzzetta

Anesthesiology

DOI: 10.1097/ALN.0000000000001058

21. Comprehensive Assessment of Coronary Plaque Progression with Advanced Intravascular Imaging, Physiologic Measures and Wall Shear Stress: A Double-Blinded Randomized-Controlled Clinical Trial of Nebivolol vs. Atenolol in Non-obstructive Coronary Artery Disease

Olivia Y. Hung, David Molony, Michel T. Corban, Emad Rasoul‐Arzrumly, Charles Maynard, Parham Eshtehardi, Saurabh Dhawan, Lucas H. Timmins, Marina Piccinelli, Sung Gyun Ahn, Bill D. Gogas, Michael C. McDaniel, Arshed A. Quyyumi, Don P. Giddens, Habib Samady

Journal of the American Heart Association

DOI: 10.1161/JAHA.115.002764

2015

20. Do-it-yourself In Vitro Vasculature that Recapitulates Complex In Vivo Geometries for Investigating Endothelial-blood Cell Interactions

Robert G. Mannino, David R. Myers, Byungwook Ahn, Yichen Wang, Margo Rollins, Hope Gole, Angela S. Lin, Robert E. Guldberg, Don P. Giddens, Lucas H. Timmins, Wilbur A. Lam

Scientific Reports

DOI: 10.1038/srep12401

19. Co-localization of Disturbed Flow Patterns and Occlusive Cardiac Allograft Vasculopathy Lesion Formation in Heart Transplant Patients

Lucas H. Timmins, Divya Gupta, Michel T. Corban, David S. Molony, John N. Oshinski, Habib Samady, Don P Giddens

Cardiovascular Engineering and Technology

DOI: 10.1007/s13239-014-0198-2

18. An Assessment of Intra-Patient Variability on Observed Relationships Between Wall Shear Stress and Plaque Progression in Coronary Arteries

David S. Molony, Lucas H. Timmins, Olivia Y. Hung, Emad Rasoul-Arzrumly, Habib Samady, Don P. Giddens

BioMedical Engineering OnLine

DOI: 10.1186/1475-925X-14-S1-S2

17. Focal Association Between Wall Shear Stress and Clinical Coronary Artery Disease Progression

Lucas H. Timmins, David S. Molony, Parham Eshtehardi, Michael C. McDaniel, John N. Oshinski, Habib Samady, Don P. Giddens

Annals of Biomedical Engineering

DOI: 10.1007/s10439-014-1155-9

2014

16. Biomechanics and Inflammation in Atherosclerotic Plaque Erosion and Plaque Rupture: Implications for Cardiovascular Events in Women

Ian C. Campbell, Jonathan D. Suever, Lucas H. Timmins, Alessandro Veneziani, Raymond P. Vito, Renu Virmani, John N. Oshinski, W. Robert Taylor

PLoS ONE

DOI: 10.1371/journal.pone.0111785

15. Myocardial Bridging: Evolving Understanding of Pathophysiology and Contemporary Diagnostic and Therapeutic Strategies

Michel T. Corban, Olivia Y. Hung, Parham Eshtehardi, Emad Rasoul-Arzrumly, Michael McDaniel, Girum Mekonnen, Lucas H. Timmins, Jerre Lutz, Robert A. Guyton, Habib Samady

Journal of the American College of Cardiology

DOI: 10.1016/j.jacc.2014.01.049

14. Combination of Plaque Burden, Wall Shear Stress, and Plaque Phenotype has Incremental Value for Prediction of Coronary Atherosclerotic Plaque Progression and Vulnerability

Michel T. Corban, Parham Eshtehardi, Jin Suo, Michael C. McDaniel,     Lucas H. Timmins, Emad Rassoul-Arzrumly, Charles Maynard, Girum Mekonnen, Spencer King III, Arshed A. Quyyumi, Don P. Giddens, Habib Samady

Atherosclerosis

DOI: 10.1016/j.atherosclerosis.2013.11.049

2013

13. Co-localization of Low and Oscillatory Coronary Wall Shear Stress with Subsequent Culprit Lesion Resulting in Myocardial Infarction in an Orthotopic Heart Transplant Patient

Lucas H. Timmins, Benjamin D. Mackie, John N. Oshinski, Don P. Giddens, Habib Samady
JACC: Cardiovascular Interventions
DOI: 10.1016/j.jcin.2013.03.024

12. Computational Fluid Dynamics Simulations of Hemodynamics in Plaque Erosion

Ian C. Campbell, Lucas H. Timmins, Don P. Giddens, Renu Virmani, Alessandro Veneziani, S. Tanveer Rab, Habib Samady, Michael C. McDaniel, Aloke V. Finn, W. Robert Taylor, John N. Oshinski
Cardiovascular Engineering and Technology
DOI: 10.1007/s13239-013-0165-3

11. Framework to Co-register Longitudinal Virtual Histology-Intravascular Ultrasound Data in the Circumferential Direction

Lucas H. Timmins, Jonathan D. Suever, Parham Eshtehardi, Michael C. McDaniel, John N. Oshinski, Habib Samady, Don P. Giddens

IEEE Transactions on Medical Imaging
DOI: 10.1109/TMI.2013.2269275

10. Biomechanical Assessment of Fully Bioresorbable Devices

Bill D. Gogas, Spencer B. King, Lucas H. Timmins, Tiziano Passerini, Marina Piccinelli, Alessandro Veneziani, Sungho Kim, David S. Molony, Don P. Giddens, Patrick W. Serruys, Habib Samady

JACC: Cardiovascular Interventions

DOI: 10.1016/j.jcin.2013.04.008

2012

9. Association of Coronary Wall Shear Stress with Atherosclerotic Plaque Burden, Composition, and Distribution in Patients with Coronary Artery Disease

Parham Eshtehardi, Michael C. McDaniel, Jin Suo, Saurabh S. Dhawan, Lucas H. Timmins, José Nilo G. Binongo, Lucas J. Golub, Michel T. Corban, Aloke V. Finn, John N. Oshinsk, Arshed A. Quyyumi, Don P. Giddens,     Habib Samady

Journal of the American Heart Association

DOI: 10.1161/JAHA.112.002543

2011

8. Coronary Artery Wall Shear Stress is Associated with Progression and Transformation of Atherosclerotic Plaque and Arterial Remodeling in Patients with Coronary Artery Disease

Habib Samady, Parham Eshtehardi, Michael C. McDaniel, Jin Suo, Saurabh S. Dhawan, Charles Maynard, Lucas H. Timmins, Arshed A. Quyyumi,       Don P. Giddens

Circulation

DOI: 10.1161/CIRCULATIONAHA.111.021824

7. Increased Artery Wall Stress Post-Stenting Leads to Greater Intimal Thickening

Lucas H. Timmins, Matthew W. Miller, Fred J. Clubb, James E. Moore, Jr.

Laboratory Investigations

DOI: 10.1038/labinvest.2011.57

2010

6. Coronary Artery Bifurcation Biomechanics and Implications for Interventional Strategies

James E. Moore Jr., Lucas H. Timmins, John F. LaDisa Jr.

Catheterization and Cardiovascular Interventions

DOI: 10.1002/ccd.22596

5. Structural Inhomogeneity and Fiber Orientation in the Inner Arterial Media

Lucas H. Timmins, Qiaofeng Wu, Alvin T. Yeh, James E. Moore Jr.,     Stephen E. Greenwald

American Journal of Physiology – Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00891.2009

2008

4. Effects of Stent Design and Atherosclerotic Plaque Composition on Arterial Wall Biomechanics

Lucas H. Timmins, Clark A. Meyer, Michael R. Moreno, James E. Moore Jr.

Journal of Endovascular Therapy

DOI: 10.1583/08-2443.1

3. Mechanical Modeling of Stents Deployed in Tapered Arteries

Lucas H. Timmins, Clark A. Meyer, Michael R. Moreno, James E. Moore, Jr.

Annals of Biomedical Engineering

DOI: 10.1007/s10439-008-9582-0

2007

2. Stented Artery Biomechanics and Device Design Optimization

Lucas H. Timmins, Michael R. Moreno, Clark A. Meyer, John C. Criscione, Alexander Rachev, James E. Moore, Jr.

Medical & Biological Engineering & Computing

DOI: 10.1007/s11517-007-0180-3

2006

Effects of Stent Design Parameters on Normal Artery Wall Mechanics

Julian Bedoya, Clark A. Meyer, Lucas H. Timmins, Michael R. Moreno,     James E. Moore Jr.       

ASME Journal of Biomechanical Engineering

DOI: 10.1115/1.2246236

Book Chapters

2021

Effect of Regional Analysis Methods on Assessing the Association Between Wall Shear Stress and Coronary Artery Disease Progression in the Clinical Setting

in Biomechanics of Coronary Atherosclerotic Plaques: From Model to Patient, Ohayon, J., Finet, G., Pettigrew, R.I. (Eds.), Elsevier, Philadelphia, PA.

Lucas H Timmins, Habib Samady, John N Oshinski

DOI: 10.1016/B978-0-12-817195-0.00009-3

2014

Investigation of the Influence of Side-Branches on Wall Shear Stress in Coronary Arteries Reconstructed from Intravascular Ultrasound

in Computational Biomechanics for Medicine: Fundamental Science and Patient-specific Applications, Doyle, B., Miller, K., Wittek, A., Nielson, P.M.F. (Eds.), Springer, New York, NY.

David S Molony Lucas H Timmins, Emad Rasoul-Arzrumly, Habib Samady, Don P Giddens

DOI: 10.1007/978-1-4939-0745-8_4

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